Clinical Trial SignalEvery source. Documented.
Clinical Trial Signal stands on a public-data backbone. Every signal carries a source, a source URL, a source timestamp, an ingestion timestamp, and the appropriate caveat. Nothing is paraphrased away from the primary record.
Clinical trial registries
ClinicalTrials.gov core
The U.S. National Library of Medicine's clinical trial registry. Full access to study records, status, sponsors, phases, conditions, interventions, locations, and results. Includes feeds for "recently added" and "recently modified" studies plus search-specific updates.
WHO ICTRP (International Clinical Trials Registry Platform)
WHO's meta-registry aggregating EU CTR, ISRCTN, JPRN, ANZCTR, ChiCTR, REBEC, and more. Weekly XML/CSV export gives global trial coverage outside the U.S.
EU Clinical Trials Register / CTIS
European trials under Regulation (EU) No 536/2014, now consolidating into the EMA's Clinical Trials Information System (CTIS).
ISRCTN Registry
UK-based international primary registry, complements ClinicalTrials.gov for non-U.S. registrations.
FDA & drug safety sources
openFDA FAERS (adverse-event reports) core
Public access to FAERS, the FDA Adverse Event Reporting System, the post-market surveillance database for drugs and therapeutic biologics. Reports come from healthcare professionals, consumers, and manufacturers.
openFDA Drug Enforcement / Recalls core
FDA Recall Enterprise System data. Drug recall records from 2004 to present, updated weekly. Includes classification (Class I/II/III), reason, distribution, and product detail.
openFDA Drug Labels · DailyMed labeling
Structured Product Labeling (SPL) data — indications, adverse reactions, warnings, contraindications. DailyMed is the canonical NLM source for the most recent labels currently in use.
FDA MedWatch & Drug Safety Communications
Official FDA channel for MedWatch safety alerts, drug safety communications, recalls, and press releases.
VAERS (Vaccine Adverse Event Reporting System)
HHS/CDC public CSV download. Vaccine-side equivalent of FAERS. Same reporting-bias caveats apply.
FDA Orange Book Data Files
Therapeutic equivalence, patents, exclusivity, generic competition. Monthly downloadable data.
Drugs@FDA — approvals & Complete Response Letters core
FDA's drug approval history. Approval letters, Complete Response Letters (regulatory rejections), labeling supplements, post-marketing requirements, and approval-package documents. Critical for distinguishing successful filings from rejections and additional-information requests.
FDA Drug Shortages
FDA's current and resolved drug-shortage list with root cause (manufacturing, supply chain, demand). Operational signal for distributors, manufacturers, and clinical operations.
Literature sources
NCBI PubMed core
Coverage of PubMed and PubMed Central for biomedical literature searches.
Europe PMC
EBI's biomedical literature aggregator. Broader than PubMed alone, includes preprints, supports full-text mining where licenses allow.
bioRxiv & medRxiv preprints
Preprints are often the earliest signal of new research — especially during active trials. Free, no key.
Sponsor & investor sources
SEC EDGAR filings core
Per-company submission data by CIK, plus per-company filings feeds.
CMS Open Payments (Sunshine Act) core
Public dataset of payments and transfers of value from drug and device manufacturers to U.S. physicians and teaching hospitals, mandated under the Physician Payments Sunshine Act. Maps the financial relationships between sponsors and investigators / key opinion leaders.
Newswire feeds — PR Newswire, GlobeNewswire, Business Wire
Sponsor press releases distributed through major investor-wire services. Clinical-milestone announcements, financing rounds, regulatory updates, executive transitions, and acquisition news for biotech and pharma issuers.
Pipeline & competitive intelligence
USPTO PatentsView core
U.S. Patent and Trademark Office's public patent dataset. Patent assignments, claims, family graphs, expiry estimates, and patent term extensions for biologics, drugs, and devices. Maps the IP perimeter around a drug or sponsor.
NIH RePORTER core
NIH's biomedical research grant database. Federal funding by principal investigator, institution, condition, and mechanism. Surfaces pre-clinical and translational research investment before it reaches a trial registry — the earliest leading indicator of a pipeline.
Regulatory & epidemiology
Federal Register
FDA rulemaking, advisory committee notices, guidance announcements.
CDC MMWR · Health Canada Drug Product Database · EMA EPAR + safety updates
Cross-jurisdictional context. MMWR for epidemiologic surveillance signals; Health Canada DPD and EMA EPAR for international approval comparison.
RxNorm (NLM)
Drug name normalization across brand, generic, and ingredient. Lets us tie FAERS / EDGAR / PubMed mentions of the same drug under different names together.
WHO VigiAccess — global pharmacovigilance
WHO Uppsala Monitoring Centre's global adverse-event database. International suspected-adverse-reaction reports submitted by over 130 member countries, complementing U.S.-focused FAERS coverage.
NICE (UK) & PMDA (Japan) decisions
UK National Institute for Health and Care Excellence health-technology appraisals and Japan's Pharmaceuticals and Medical Devices Agency approval and safety reviews. International market-access intelligence beyond FDA and EMA.